Endothelin 1

EDN1
Cấu trúc được biết đến
PDB	Tìm trên Human UniProt: PDBe RCSB
Danh sách mã id PDB
	1EDN, 1EDP, 1T7H, 1V6R, 6DK5, 5GLH
Mã định danh
Danh pháp	EDN1, ARCND3, ET1, HDLCQ7, QME, endothelin 1, PPET1
ID ngoài	HomoloGene: 1476 GeneCards: EDN1
Vị trí gen (Người)
NST	Nhiễm sắc thể 6 (người)
Kết thúc	12,297,194 bp
Mẫu hình biểu hiện RNA
	Thêm nguồn tham khảo về sự biểu hiện
Bản thể gen
Chức năng phân tử	• hormone activity; • signaling receptor binding; • cytokine activity; • endothelin B receptor binding; • GO:0001948, GO:0016582 protein binding; • endothelin A receptor binding;
Thành phần tế bào	• tế bào chất; • Weibel-Palade body; • basal part of cell; • extracellular region; • rough endoplasmic reticulum lumen; • extracellular space; • transport vesicle;
Quá trình sinh học	• skeletal system development; • response to amino acid; • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; • positive regulation of MAP kinase activity; • regulation of sensory perception of pain; • Co mạch máu; • body fluid secretion; • positive regulation of sarcomere organization; • positive regulation of cardiac muscle hypertrophy; • cell surface receptor signaling pathway; • multicellular organism aging; • artery smooth muscle contraction; • cellular response to interferon-gamma; • positive regulation of chemokine-mediated signaling pathway; • phosphatidylinositol 3-kinase signaling; • response to leptin; • positive regulation of mitotic nuclear division; • cellular response to hypoxia; • response to muscle stretch; • cellular response to calcium ion; • cellular response to transforming growth factor beta stimulus; • positive regulation of renal sodium excretion; • blood vessel morphogenesis; • negative regulation of blood coagulation; • response to nicotine; • in utero embryonic development; • neutrophil chemotaxis; • heart development; • positive regulation of prostaglandin secretion; • vein smooth muscle contraction; • cartilage development; • rhythmic excitation; • protein kinase C-activating G protein-coupled receptor signaling pathway; • cellular response to glucocorticoid stimulus; • branching involved in blood vessel morphogenesis; • negative regulation of hormone secretion; • positive regulation of smooth muscle contraction; • negative regulation of nitric-oxide synthase biosynthetic process; • positive regulation of prostaglandin-endoperoxide synthase activity; • positive regulation of urine volume; • positive regulation of JUN kinase activity; • leukocyte activation; • membrane depolarization; • GO:1901227 negative regulation of transcription by RNA polymerase II; • response to ozone; • respiratory gaseous exchange by respiratory system; • positive regulation of heart rate; • regulation of blood pressure; • response to lipopolysaccharide; • response to prostaglandin F; • regulation of vasoconstriction; • cellular response to interleukin-1; • response to salt; • positive regulation of cell size; • middle ear morphogenesis; • sensory perception of pain; • prostaglandin biosynthetic process; • dorsal/ventral pattern formation; • phospholipase D-activating G protein-coupled receptor signaling pathway; • positive regulation of odontogenesis; • regulation of pH; • positive regulation of smooth muscle cell proliferation; • protein kinase C deactivation; • histamine secretion; • maternal process involved in parturition; • GO:0007243 intracellular signal transduction; • response to hypoxia; • neural crest cell development; • regulation of systemic arterial blood pressure by endothelin; • nitric oxide transport; • positive regulation of cell migration; • response to testosterone; • positive regulation of cytosolic calcium ion concentration; • epithelial fluid transport; • positive regulation of nitric oxide biosynthetic process; • cell-cell signaling; • cellular response to tumor necrosis factor; • response to activity; • response to dexamethasone; • superoxide anion generation; • positive regulation of endothelial cell migration; • cellular response to peptide hormone stimulus; • cellular response to fatty acid; • peptide hormone secretion; • cellular response to mineralocorticoid stimulus; • positive regulation of cell population proliferation; • inositol phosphate-mediated signaling; • positive regulation of hormone secretion; • negative regulation of smooth muscle cell apoptotic process; • calcium-mediated signaling; • response to transforming growth factor beta; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of DNA-binding transcription factor activity; • positive regulation of cell growth involved in cardiac muscle cell development; • positive regulation of neutrophil chemotaxis; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; • regulation of glucose transmembrane transport; • negative regulation of gene expression; • positive regulation of NIK/NF-kappaB signaling; • positive regulation of vascular associated smooth muscle cell proliferation;
	Nguồn: Amigo / QuickGO
Gen cùng nguồn
	1906
	n/a
	ENSG00000078401
	n/a
	P05305
	n/a
	NM_001168319; NM_001955
	n/a
	NP_001161791; NP_001946; NP_001161791; NP_001946
	n/a
	Wikidata
Xem/Sửa Người

Endothelin 1 (ET-1), còn được gọi là preproendothelin-1 (PPET1), là một thuốc co mạch mạnh ở người được mã hóa bởi gen EDN1 và được sản xuất bởi các tế bào nội mô mạch máu. Protein được mã hóa bởi gen này được xử lý protein để giải phóng một peptide được tiết ra có tên là endothelin 1. Endothelin 1 là một trong ba dạng đồng phân của endothelin ở người.

Preproendothelin là tiền chất của peptide ET-1. Các tế bào nội mô chuyển đổi preproendothelin thành proendothelin và sau đó thành endothelin trưởng thành, tế bào giải phóng.^[3]

Thuốc đối kháng thụ thể endothelin-1 (Bosentan) được sử dụng trong điều trị tăng áp phổi. Sự ức chế các thụ thể này ngăn ngừa co thắt mạch phổi và do đó làm giảm sức cản mạch máu phổi.

Tham khảo

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078401 - Ensembl, May 2017
^ “Human PubMed Reference:”.
^ Boulpaep EL, Boron WF (2009). Medical physiology: a cellular and molecular approach. Saunders/Elsevier. ISBN 1-4160-3115-4.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078401 - Ensembl, May 2017

[2] “Human PubMed Reference:”.

[isbn1-4160-3115-4-3] Boulpaep EL, Boron WF (2009). Medical physiology: a cellular and molecular approach. Saunders/Elsevier. ISBN 1-4160-3115-4.

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