EXOSC10

Thành phần exosome 10 (tiếng Anh: Exosome component 10), còn được gọi là EXOSC10, là gen ở người, sản phẩm protein của gen là thành phần cấu thành phức hệ exosome và là một tự kháng nguyên (autoantigen), trở thành một mầm bệnh, dẫn đến sinh bệnh tự miễn, nổi bật nhất là chứng scleromyositis.

EXOSC10
Cấu trúc được biết đến PDB Tìm trên Human UniProt: PDBe RCSB Danh sách mã id PDB 2CPR, 3SAF, 3SAG, 3SAH
Mã định danh
Danh pháp	EXOSC10, PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4, exosome component 10
ID ngoài	OMIM: 605960 HomoloGene: 31105 GeneCards: EXOSC10
Mẫu hình biểu hiện RNA Thêm nguồn tham khảo về sự biểu hiện
Bản thể gen Chức năng phân tử • nucleotide binding • exoribonuclease activity • GO:0001948, GO:0016582 protein binding • catalytic activity • 3'-5' exonuclease activity • nucleic acid binding • nuclease activity • exonuclease activity • hydrolase activity • RNA binding • 3'-5'-exoribonuclease activity • telomerase RNA binding • single-stranded RNA binding Thành phần tế bào • tế bào chất • exosome (RNase complex) • membrane • nuclear exosome (RNase complex) • nội bào • Hạch nhân • nhân tế bào • Chất nhân • cytosol Quá trình sinh học • GO:0033168, GO:0036404, GO:1902360 RNA processing • nuclear polyadenylation-dependent rRNA catabolic process • nucleic acid phosphodiester bond hydrolysis • CUT catabolic process • nuclear-transcribed mRNA catabolic process • GO:0071049, GO:0071048, GO:0071033 nuclear mRNA surveillance • cell metabolism • maturation of 5.8S rRNA • histone mRNA catabolic process • dosage compensation by inactivation of X chromosome • nucleobase-containing compound metabolic process • rRNA processing • RNA phosphodiester bond hydrolysis, exonucleolytic • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • negative regulation of telomere maintenance via telomerase • regulation of telomerase RNA localization to Cajal body • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • nuclear polyadenylation-dependent snoRNA catabolic process • nuclear polyadenylation-dependent snRNA catabolic process • nuclear polyadenylation-dependent tRNA catabolic process • nuclear polyadenylation-dependent CUT catabolic process • nuclear polyadenylation-dependent antisense transcript catabolic process • polyadenylation-dependent snoRNA 3'-end processing Nguồn: Amigo / QuickGO
Gen cùng nguồn
Loài	Người	Chuột
Entrez	5394	n/a
Ensembl	ENSG00000171824	n/a
UniProt	Q01780	n/a
RefSeq (mRNA)	NM_001001998 NM_002685	n/a
RefSeq (protein)	NP_001001998 NP_002676	n/a
Vị trí gen (UCSC)	n/a	n/a
PubMed		n/a
Wikidata
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Đọc thêm

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